Author: Matthew Rupp

Mutation Bias as an Evolutionary Driver

By Matthew Rupp on December 15, 2015 in Research / 0 Comments
Mutation Bias as an Evolutionary Driver

If mutation is the ultimate source of genetic novelty, can a bias of mutation inflow alter the evolutionary trajectory of a population? On the surface, it would appear the answer should be yes. Intuitively, the path through genotype space should be influenced by the manner in which mutations are introduced into the population. For an easy to digest analogy, consider a rephrased thought experiment proposed by Stoltzfus and Yampolsky called “Climbing Mount Probable” [Stoltzfus, A., & Yampolsky, L. Y. (2009). Climbing mount probable: Mutation as a cause of nonrandomness in evolution. Journal of Heredity, 100(5), 637–647]. Beginning with the 80 year old fitness-landscape as a mountain analogy, we can envision a population of haploid organisms clustered about the face of a mountain with the organisms’ elevation representing their absolute fitnesses. Genetic novelty introduced through mutation during […]